Paget's disease of bone: Updates for clinicians. Clinical manifestations and diagnosis of Paget disease of bone. Bone cancer occurs in up to 1% of people with Paget's disease of bone. Sometimes, this increased workload can lead to heart failure. In severe cases, your heart may have to work harder to pump blood to the affected areas of your body.
When Paget's disease of bone occurs in an area where nerves pass through the bone, such as the spine and skull, the overgrowth of bone can compress and damage the nerve, causing pain, weakness or tingling in an arm or leg or hearing loss. Misshapen bones can increase the amount of stress on nearby joints, which can cause osteoarthritis. Leg bones can bow, which can affect your ability to walk. Affected bones break more easily, and extra blood vessels in these deformed bones cause them to bleed more during repair surgeries. The disease can be managed effectively in nearly all people. In most cases, Paget's disease of bone progresses slowly. If you have a relative who has Paget's disease of bone, you're more likely to develop the condition. Paget's disease of bone is more common in England, Scotland, central Europe and Greece - as well as countries settled by European immigrants. Men are more commonly affected than are women. People older than 50 are most likely to develop the disease. Risk factorsįactors that can increase your risk of Paget's disease of bone include: Some scientists believe Paget's disease of bone is related to a viral infection in your bone cells, but this theory is controversial. Several genes appear to be linked to getting the disease. Scientists suspect a combination of environmental and genetic factors contribute to the disease. The cause of Paget's disease of bone is unknown. Unexplained hearing loss, especially if it's only on one side.Enlarged and misshapen bones in your legs can put extra stress on nearby joints, which may cause osteoarthritis in your knee or hip. As the bones weaken, they may bend - causing you to become bowlegged. This can cause pain, tingling and numbness in an arm or leg. If your spine is affected, nerve roots can become compressed. An overgrowth of bone in the skull can cause hearing loss or headaches. Paget's disease of bone in the pelvis can cause hip pain. Your signs and symptoms, if any, will depend on the affected part of your body. The disease might affect only one or two areas of your body or might be widespread. When symptoms occur, the most common complaint is bone pain.īecause this disease causes your body to generate new bone faster than normal, the rapid remodeling produces bone that's less organized and weaker than normal bone, which can lead to bone pain, deformities and fractures. Most people who have Paget's disease of bone have no symptoms.
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